What is the technology of Comprehensive Chromosomal Screening ?

CCS is a technology that makes it possible to analyse and control the chromosomes of an embryo. To get how CCS is performed to advance fertility care, let’s get informed about DNA structure.

Chromosomes & DNA | The Basics
Human beings have a total of forty-six chromosomes. Forty-four of those are mentioned as autosomes and are available in both sexes. The final combination is mentioned as the sex chromosomes (X and Y). If an embryo possess too few or too many chromosomes, it will not able to continue to live and make a live delivery. Special cases do exist, including Down’s disorder (Trisomy 21, which is three duplicates of the 21st chromosome). Different special cases are Trisomy 13 and 18 (3 duplicates of chromosome 13 and 18 individually), where notwithstanding being live conceived, these posterity infrequently endure in excess of a couple of months because of extreme birth abandons. A few instances of too numerous or too few sex chromosomes, for example, Turner’s Syndrome where there are just 45 add up to chromosomes (just a single X) and Klinefelter’s Syndrome where there are 47 add up to chromosomes (two X’s and one Y), can endure.

What is Comprehensive Chromosome Screening (CCS)?
CCS enables us to resolve, at the embryo stage, how many chromosomes are present and therefore whether the embryo has the probability to make a live birth. This technology enables us to identify embryos that may be able to establish a pregnancy, such as Trisomy 16 or Trisomy 22, however, but have a 0% chance of making a live birth and will always result in miscarriage.

How is CCS Different from PGD?
CCS enables us to assess the chromosomes of an embryo and therefore serves as a monitoring tool. PGD (Pre-implantation Genetic Diagnosis) enables us to see if an embryo has a specific disease. For example there are lethal diseases, such as Tay Sachs Syndrome, which are recessive gene diseases. This means that the parents were carriers of the abnormal gene, but since they had a normal gene on the other chromosome, they do not have the disease. If two carriers reproduce, one quarter of the offspring will inherit the abnormal gene from each parent and therefore will have the actual disease. PGD enables us to resolve whether a specific embryo carries no copies, one copy or two copies of the abnormal gene (i.e. normal state, is a carrier or actually has the disease). PGD is useful when we know exactly what disease we are looking for. It is a truly diagnostic test whereas CCS is a monitoring tool.

Who Should Consider CCS?
CCS is very useful for couples that are at risk of chromosomal problems. The broadest category would be older parents, typically late 30s and older. It is very clear that older women (and this applies to older men as well although at a lower rate) are at an increased risk for miscarriages and Down’s syndrome. CCS enables us to identify which embryos are chromosomally abnormal. CCS is useful for couples that may have had multiple unexplained miscarriages because we would be able to get a better sense of whether miscarriages are caused by abnormal embryos or an abnormal uterine environment. CCS also sheds light on couples who are not responding to routine fertility treatment and have had repeated failure.

How Does CCS Increase IVF Success?
CCS enables us to exclude abnormal embryos that have no chance of making a healthy baby. This will reduce the number of embryo transfers necessary to find the “right embryo.” In this fashion, it will increase the efficiency of the process and the success of in vitro fertilization (IVF). Also, since we have ruled out the abnormal embryos, the embryos which CCS has shown to have a normal number of chromosomes are far more likely to implant. Therefore we can remain conservative, and transfer just one embryo at a time, thereby eliminating the risk of a multiple pregnancy.

IVF with CCS Success Rates
IVF by itself is already an extraordinarily powerful tool in reproductive medicine. Whereas the normal human fecundity rate (likelihood of pregnancy per cycle) is ~20%, IVF fecundity rates are almost twice as high as that (when we average all ages together). IVF with CCS rates are higher yet, surpassing 60% because we can further fine-tune the process of identifying which embryos to consider for transfer into the uterus.

Which countries provide CCS?
Most of the countries like Denmark, UK, Russia, Turkey, Cyprus, Georgia, India, Greece, Sweden, Albania, Andorra, Hungary, Romania, Spain, Dubai, France, Italy, Bulgaria, Estonia, Norway, Switzerland, Finland, Azerbaijan.

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